Anti-Tyrosine Hydroxylase antibody GTX113016 from GeneTex

Product Specs
ItemAnti-Tyrosine Hydroxylase antibody
CompanyGeneTex
Price $169.00Supplier Page
Catalog NumberGTX113016
Conjugate/TagUnconjugated
ReactivityHuman, Mouse, Rat, Zebrafish, Vole, Calf
Quantity25 µl
HostRabbit
FormatPBS, 1% BSA, 20% Glycerol, 0.025% ProClin 300
ClonalityPolyclonal
ApplicationsWB, ICC/IF, IHC-P, IHC-Fr
ImmunogenRecombinant protein encompassing a sequence within the center region of human Tyrosine Hydroxylase. The exact sequence is proprietary
Concentration0.21mg/ml
IsotypeIgG
Antibody TypePrimary Antibodies
NCBI Full Gene Nametyrosine hydroxylase
NCBI Gene AliasesDYT14, tyrosine hydroxylase, DYT14, DYT5b, TYH, DYT5b, TYH
PurityPurified by antigen-affinity chromatography
TargetTyrosine Hydroxylase
Research AreaNeuroscience
Gene NameTH
Molecular Weight59

Questions and Answers

What species does this antibody recognize, and has it been used in relevant studies?

The Anti-Tyrosine Hydroxylase antibody recognizes several species including human, mouse, rat, zebrafish, vole, and calf. It has been utilized in various studies, such as in the identification of dopaminergic neurons in the substantia nigra of rat models of Parkinson's disease, where it was used for immunohistochemistry to label these neurons ().

Can this antibody be effectively used in immunohistochemistry, and what are some examples of its application?

Yes, the Anti-Tyrosine Hydroxylase antibody has been validated for use in immunohistochemistry. It has been cited in studies where it was employed to visualize tyrosine hydroxylase expression in various models, including in the context of neuroinflammation and neurodegenerative diseases (, ).

Is there any information on the concentration and dilution recommended for using this antibody in experiments?

The recommended dilution for the Anti-Tyrosine Hydroxylase antibody in immunohistochemistry is typically around 1:200 to 1:1000, as seen in various studies where it was used to detect tyrosine hydroxylase in brain tissues (, ).

How does this antibody perform in Western blot applications based on existing literature?

The Anti-Tyrosine Hydroxylase antibody has been successfully used in Western blot applications, where it has been shown to detect tyrosine hydroxylase protein levels in various experimental setups, including studies investigating signaling pathways related to addiction and neurodegeneration ().

GeneTex

GeneTex, Inc. 2456 Alton Parkway

Irvine, California 92606

United States

Phone: 1-877-GeneTex (436-3839) or 949-553-1900
Fax: 949-309-2888

Company Profile

Website: http://www.genetex.com

(1) Neural cell state modulation by PARK2 and dopaminergic neuroprotection by small molecule Parkin agonismbioRxivApril 4, 2026Yongxing Gong, Armin Bayati, Tyler J. Alban, Prerana Parthasarathy, Fang Zhou, Vladimir Makarov, Yuhang Zhao, Chienwen Su, Jackson G. Schumacher, Vijay Singh, et al.were washed with PBS and stained for pSyn (Abcam, ab51253), Tuj1 (Abcam, ab41489), and TH (Genetex, GTX113016), following permeabilization and blocking with 5% Bovine Serum Albumin (Millipore Sigma, A9647-100G)

(2) Ferroptosis inhibition protects against α-synuclein-related neuronal cell deathCell Death & DiseaseDecember 14, 2025Naďa Majerníková, Maria J. Caiado, Renée I. Seinstra, Suzanne Couzijn, María E. Goya, Casandra Salinas Salinas, Hannah Truong, Tineke van der Sluis, Anneke Miedema, Leon C. L. T. van Kempen, et al.dopaminergic neurons, the TMA was then stained with 1:200 primary anti-Tyrosine Hydroxylase (TH) antibody (Cat#GTX113016, Genetex), combined with 1:10 SYTO13 nuclear stain (Cat# 121300303, Nanostring) (directly conjugated

(3) Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activityeLifeOctober 9, 2025Hiroki Toyoda, Doyun Kim, Byeong Geon Koh, Tomomi Sano, Takashi Kanematsu, Seog Bae Oh, Youngnam Kanganti-sodium potassium ATPase (1:1000; ab76020, Abchem) (Figure 3C, F, and G); rabbit anti-TH (1:1600; GTX113016, GeneTex, Irvine, CA, USA), rabbit anti-MAO-A (1:6400; ab126751, Abcam), mouse anti-legumain (AEP) (1:400;

(4) Dopamine Drives Feedforward Inhibition to Orexin Feeding System, Mediating Weight Loss Induced by Morphine AddictionAdvanced ScienceJanuary 21, 2025Huiming Li, Sa Wang, Dan Wang, Jiannan Li, Ge Song, Yongxin Guo, Lu Yin, Tingting Tong, Haopeng Zhang, Hailong Dong1:1000), anti‐OrexinA (MAB763, R&D Systems; 1:500), anti‐GABA (GTX125988, GeneTex; 1:200), and anti‐TH (GTX113016, GeneTex; 1:1000). Secondary antibodies were incubated at room temperature for 2 h, including Donkey

(5) CAR+ extracellular vesicles predict ICANS in patients with B cell lymphomas treated with CD19-directed CAR T cellsThe Journal of clinical investigationJune 4, 2024Storci G, De Felice F, Ricci F, Santi S, Messelodi D, Bertuccio SN, Laprovitera N, Dicataldo M, Rossini L, De Matteis S, et al.RRID:AB_2732785), β3-tubulin (Abcam catalog ab78078, RRID:AB_2256751), tyrosine hydroxylase (GeneTex catalog GTX113016, RRID:AB_1952230). After 3 PBS washes, samples were stained with the appropriate secondary fluorochrome-conjugated

(6) The selective serotonin reuptake inhibitor paroxetine improves right ventricular systolic function in experimental pulmonary hypertensionJournal of Molecular and Cellular Cardiology PlusJune 1, 2024Mark T. Waddingham, Hirotsugu Tsuchimochi, Takashi Sonobe, Vasco Sequeira, Md Junayed Nayeem, Mikiyasu Shirai, James T. Pearson, Takeshi OgoNBP2–37611), β1AR (1:100, Santa Cruz Biotechnology, sc-568), tyrosine hydroxylase (1:1000; GeneTex, GTX113016), phospho-cMyBP-CSer282 (1:1000; Enzo Lifesciences, ALX-215-057-R050), phospho-cTnISer23/24 (1:1000,

(7) Klotho Null Mutation Indirectly Leads to Age-Related Lacrimal Gland Degeneration in Mutant MiceBiologyOctober 11, 2023Wu CY, Song DF, Lu TH, Chen ZJ, Tsai SM, Liu YJ, Chang HH, Lin DP.no. GTX129461, dilution at 1/500), anti-TH (tyrosine hydroxylase) (GeneTex, Irvine, CA, USA, cat no. GTX113016, dilution at 1/500), MMP-2 (GeneTex, Irvine, CA, USA, cat. no. 104577, dilution at 1/500), MMP-9 (Abcam,

(8) Chemogenetic Activation of Oxytocin Neurons Improves Pain in a Reserpine-induced Fibromyalgia Rat ModelNeuroscienceSeptember 15, 2023Ikeda N, Kawasaki M, Baba K, Nishimura H, Fujitani T, Suzuki H, Matsuura T, Ohnishi H, Shimizu M, Sanada K, et al.

(9) Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABANeuronApril 5, 2023Yang J, Chen J, Liu Y, Chen KH, Baraban JM, Qiu Z.1:500, Millipore, AB1574), anti-TH (mouse, 1:1000, Millipore, MAB318), anti-TH (rabbit, 1:1000, GeneTex, GTX113016), anti-S100β (rabbit, 1:1000, Abcam, ab41548), anti-mCherry (rat, 1:1000, Thermo Scientific, M11217),

(10) Dopaminergic Neurons in the Ventral Tegmental-Prelimbic Pathway Promote the Emergence of Rats from Sevoflurane AnesthesiaNeuroscience bulletinApril 1, 2022Song Y, Chu R, Cao F, Wang Y, Liu Y, Cao J, Guo Y, Mi W, Tong L.

(11) Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synucleinScientific reportsMarch 8, 2022Reimer L, Haikal C, Gram H, Theologidis V, Kovacs G, Ruesink H, Baun A, Nielsen J, Otzen DE, Li JY, et al.protein filament), anti-α-tubulin (T9026 Sigma-Aldrich Co.) and anti-Tyrosine Hydroxylase (GeneTex, GTX113016). Secondary antibodies: horseradish peroxidase (HRP)-conjugated polyclonal rabbit-anti-mouse (Dako,

(12) Impairment of human dopaminergic neurons at different developmental stages by perfluoro-octanoic acid (PFOA) and differential human brain areas accumulation of perfluoroalkyl chemicalsEnvironment internationalJanuary 1, 2022Di Nisio A, Pannella M, Vogiatzis S, Sut S, Dall'Acqua S, Rocca MS, Antonini A, Porzionato A, De Caro R, Bortolozzi M, et al.

(13) In Vitro Generation of Brain Regulatory T Cells by Co-culturing With AstrocytesFrontiers in immunologyJanuary 1, 2022Yamamoto S, Matsui A, Ohyagi M, Kikutake C, Harada Y, Iizuka-Koga M, Suyama M, Yoshimura A, Ito M.temperature using blocking solution (0.2% skim milk). The first antibodies were anti-TH antibody (GeneTex, GTX113016), rabbit anti-Iba1 antibody (Wako; 019-19741), and anti-phosphorylated α-synuclein antibody (pSer129)

(14) Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiologyAutophagyDecember 1, 2021El Manaa W, Duplan E, Goiran T, Lauritzen I, Vaillant Beuchot L, Lacas-Gervais S, Morais VA, You H, Qi L, Salazar M, et al.(A5316) TUBB/tubulin,Mouse,1:2000,Sigma-Aldrich (T5168) TH (tyrosine hydroxylase),Rabbit,1: 1000,GeneTex (GTX113016) SNCA,Mouse,1: 1000,BD Biosciences (610787) BECN1,Rabbit,1: 1000,Enzo Life Sciences (ADI-905-721-100) List

(15) Evidence of a new hidden neural network into deep fasciaeScientific reportsJune 16, 2021Fede C, Petrelli L, Guidolin D, Porzionato A, Pirri C, Fan C, De Caro R, Stecco C.

(16) Ninjinyoeito improves anxiety behavior in neuropeptide Y deficient zebrafishNeuropeptidesJune 1, 2021Kawabe M, Hayashi A, Komatsu M, Inui A, Shiozaki K.

(17) A preliminary study of Parkinson's gene therapy via sono-magnetic sensing gene vector for conquering extra/intracellular barriers in miceBrain stimulationMay 1, 2020Wu CY, Huang RY, Liao EC, Lin YC, Ho YJ, Chang CW, Chan HL, Huang YZ, Hsieh TH, Fan CH, et al.

(18) The Inhibition of miR-873 Provides Therapeutic Benefit in a Lipopolysaccharide-Induced Neuroinflammatory Model of Parkinson's DiseaseOxidative medicine and cellular longevityJanuary 1, 2020Wu J, Yu X, Xue K, Wu J, Wang R, Xie X, Li K, Yang Z, Yue J.were incubated with a polyclonal rabbit anti-rat tyrosine hydroxylase (TH) antibody (1 : 200, Cat. GTX113016; GeneTex Inc., Irvine, CA, USA). The samples were incubated with biotinylated anti-rabbit IgG (1 : 100,

(19) Understanding the Mechanism of Antidepressant-Related Sexual Dysfunction: Inhibition of Tyrosine Hydroxylase in Dopaminergic Neurons after Treatment with Paroxetine but Not with Agomelatine in Male RatsJournal of clinical medicineJanuary 23, 2019Santana Y, Montejo AL, Martín J, LLorca G, Bueno G, Blázquez JL.

(20) Cervical ganglioneuroblastoma in a new born Japanese Black calfThe Journal of veterinary medical scienceMay 18, 2018Park CH, Shiwa N, Kimitsuki K, Kakizaki T, Watanabe D.

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Anti-Tyrosine Hydroxylase antibody

Anti-Tyrosine Hydroxylase antibody

Anti-Tyrosine Hydroxylase antibody

Anti-Tyrosine Hydroxylase antibody from GeneTex

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Anti-Tyrosine Hydroxylase antibody from GeneTex

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