The Rabbit anti-human DNA replication licensing factor MCM7 polyclonal Antibody(MCM7) from MyBioSource.com is a Rabbit Polyclonal antibody to MCM7. This antibody recognizes Human antigen. The Rabbit anti-human DNA replication licensing factor MCM7 polyclonal Antibody(MCM7) has been shown to work in the following applications: ELISA, and Immunohistochemistry.
Description
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage