The Rabbit anti-human Granzyme B polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to GZMB. This antibody recognizes Human antigen. The Rabbit anti-human Granzyme B polyclonal Antibody has been shown to work in the following applications: ELISA, and Western Blot.
Description
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface nonself antigens, usually peptides or proteins resulting from infection by intracellular pathogens. This protein is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response