The Rabbit Anti-NEDD8 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to NEDD8, and NEDD8 ubiquitin like modifier. This antibody recognizes Human, and Mouse antigen. The Rabbit Anti-NEDD8 Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins