MyBioSource.com's MITF Antibody is a Mouse monoclonal antibody. The MITF Antibody was generated using Mitf as the antigen. It reacts with Human, Mouse, and Rat. This antibody has been shown to work in applications such as: Western Blot.
Description
Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'- CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest- derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium