HRI Polyclonal Antibody MBS2538144 from MyBioSource.com

Product Specs
ItemHRI Polyclonal Antibody
CompanyMyBioSource.com
Price $195.00Supplier Page View Company Product Page
Catalog NumberMBS2538144
Quantity0.06 mL
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Concentration1 mg/ml
Conjugate/TagUnconjugated
PurityAntigen Affinity Purified
ReactivityHuman, Mouse, Monkey
TargetHRI
IsotypeIgG
Molecular WeightCalculated MW: 71
Observed MW: 71
HostRabbit
ClonalityPolyclonal

Questions and Answers

Can this antibody be used for Western blotting in my studies on stress granules?

Yes, the HRI Polyclonal Antibody has been successfully utilized in Western blotting, as demonstrated in studies analyzing stress granule formation during coronavirus infections, specifically in the context of SARS-CoV-2 and HCoV-OC43 ().

Is this antibody effective for immunohistochemistry applications?

The HRI Polyclonal Antibody is suitable for immunohistochemistry applications, although specific examples of its use in this context are not detailed in the provided literature. However, its reactivity with human, mouse, and non-human primate tissues suggests potential utility in various histological studies.

What role does the HRI protein play in cellular stress responses?

The HRI protein is involved in the integrated stress response, particularly in mediating responses to endoplasmic reticulum stress. It has been shown to activate the integrated stress response upon treatment with compounds like fluorizoline, which induces apoptosis through the activation of stress-related pathways ().

Has this antibody been cited in any significant research studies?

Yes, the HRI Polyclonal Antibody has been cited in at least two scientific articles, indicating its relevance and application in current research, particularly in studies related to myelodysplastic syndromes and stress granule dynamics during viral infections (, ).

MyBioSource.com

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San Diego, California

United States

Phone: 1-888-627-0165 (toll free) or 1-858-633-0165
Fax: 1-858-633-0166

Email: sales@mybiosource.com

Company Profile

Website: http://www.MyBioSource.com

(1) Pharmacological targeting of RIG-I can selectively activate the integrated stress responseSci AdvOctober 31, 2025Caroline A. Cuoco, Wen Ren, Kelsey R. Baron, Sakina Gologo, Valerie Perea, Prakhyat Mathur, Prerona Bora, Amina Ta, Alan Chu, Rama Aldakhlallah, et al.(Cell Signaling Technology, 2118), ATF4 (Sigma-Aldrich, ABE387), FLAG (Sigma-Aldrich, F1804), HRI (MybioSource, MBS2538144), eIF2α (Cell Signaling Technology, 3398), and α-tubulin (Cell Signaling Technology, 2144) were purchased

(2) Mitochondrial damage in muscle specific PolG mutant mice activates the integrated stress response and disrupts the mitochondrial folate cycleNat CommunMarch 8, 2025Simon T. Bond, Emily J. King, Shannen M. Walker, Christine Yang, Yingying Liu, Kevin H. Liu, Aowen Zhuang, Aaron W. Jurrjens, Haoyun A. Fang, Luke E. Formosa, et al.Akt1/2,Rabbit,60,CST,4691 NDUFA9,Rabbit,39,In-house (Monash),- EIF2AK1 (HRI),Rabbit,71,MyBioSource,MBS2538144 OMA1,Mouse,40/60,Santa Cruz,sc-515788 SDHA,Mouse,71,Abcam,ab14715 LC3A/B,Rabbit,14/16,CST,12741 Ubiquitin,Rabbit,-,CST,58395 Total

(3) Growth differentiation factor 15 induces cisplatin resistance through upregulation of xCT expression and glutathione synthesis in gastric cancerCancer scienceAugust 1, 2023Wang SF, Chang YL, Fang WL, Li AF, Chen CF, Yeh TS, Hung GY, Huang KH, Lee HC.purchased from Cell Signaling Technology. Heme‐regulated eIF2α kinase Ab was purchased from MyBiosource (MBS2538144). Activating transcription factor 4 (10835‐1‐AP) Ab was obtained from Proteintech. 2.8 Small interfering

(4) The Prohibitin-Binding Compound Fluorizoline Activates the Integrated Stress Response through the eIF2α Kinase HRIInternational Journal of Molecular SciencesApril 29, 2023Ismael Sánchez-Vera, Sonia Núñez-Vázquez, José Saura-Esteller, Ana M. Cosialls, Judith Heib, Pau Nadal Rodríguez, Ouldouz Ghashghaei, Rodolfo Lavilla, Gabriel Pons, Joan Gil, et al.Sigma-Aldrich), ATF4 (D4B8, Cell Signaling), CHOP (2895, Cell Signaling), NOXA (114C307, Abcam), HRI (MBS2538144, MyBioSource), PKR (3072S, Cell Signaling), PERK (C33E10, Cell Signaling), p-PERK (Thr982) (PA5-102853,

(5) Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formationPLoS pathogensDecember 1, 2022Dolliver SM, Kleer M, Bui-Marinos MP, Ying S, Corcoran JA, Khaperskyy DA.Cell Signaling, #2956); HA tag (1:1000; mouse, Cell Signalling, #2367); HRI (1:1000, rabbit, MyBioSource, MBS2538144); HSP70 (1:1000; mouse, Santa Cruz Biotechnology, sc-32239); HSP90A/B (1:1000; mouse, Santa Cruz Biotechnology,

(6) Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood Cell Production in SF3B1-Mutant Myelodysplastic Syndromes With Ringed SideroblastsBlood Cancer DiscoveryNovember 2, 2022Vera Adema, Feiyang Ma, Rashmi Kanagal-Shamanna, Natthakan Thongon, Guillermo Montalban-Bravo, Hui Yang, Scott A. Peslak, Feng Wang, Pamela Acha, Francesc Sole, et al.standard protocols. Blotted membranes were incubated with primary polyclonal antibodies against EIF2AK1 (MBS2538144, Mybiosource), phospho-EIF2S1 (ab32157, Abcam), LC3B (2775, Cell Signaling), and vinculin (clone hVIN-1,

(7) Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathwayNatureMarch 1, 2020Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M.Technologies #3700, 1:5000), mouse anti-GFP (Roche #11814460001, 1:1000), rabbit anti-HRI (Mybiosource #MBS2538144, 1/1000), mouse anti-OMA1 (Santa Cruz Biotech # sc-515788, 1:200), rabbit anti-LonP1 (Cell Signaling Technologies

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HRI Polyclonal Antibody

HRI Polyclonal Antibody from MyBioSource.com

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HRI Polyclonal Antibody from MyBioSource.com

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