CD53 (TSPAN25) Antibody MBS439289 from MyBioSource.com

Product Specs
ItemCD53 (TSPAN25) Antibody
CompanyMyBioSource.com
Price $275.00Supplier Page View Company Product Page
Catalog NumberMBS439289
ReactivityHuman (Hu)
ClonalityMonoclonal
NCBI Gene AliasesTSPAN25, MOX44
NCBI Full Gene NameCD53 molecule
ApplicationsFCM, IF, FA
ImmunogenRecognizes a protein of 33-55kDa, identified as CD53. CD53 is expressed on monocytes, and macrophages, granulocytes, dendritic cells, osteoblasts and osteoclasts, NK cells, and on T- and B-cells from every stage of differentiation but is absent from platelets, erythrocytes, and non-haemopoietic cells. CD53 is a member of a family of tetraspan transmembrane proteins, including CD9, CD37, CD63, CD81, and CD82. It associates with integrins, MHC class II molecules, and a tyrosine phosphatase and plays a role in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. Defects of CD53 expression on neutrophils appear to be related with recurrent infectious diseases. Cross-linking CD53 using CD53 antibodies led to cytoplasmic calcium fluxes in B cells, monocytes, and granulocytes and activation of the monocyte oxidative burst
HostMouse
Clone63-5A3
Molecular WeightAntigen: 33-55kDa
IsotypeIgG2b kappa
TargetCD53
Format200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
Conjugate/TagUnconjugated
ConcentrationPurified Ab with BSA and Azide at 200ug/ml
Quantity0.1 mg