CD59 / Complement Regulatory Protein / Protectin MBS439044 from MyBioSource.com

Product Specs
ItemCD59 / Complement Regulatory Protein / Protectin
CompanyMyBioSource.com
Price $275.00Supplier Page View Company Product Page
Catalog NumberMBS439044
ReactivityHuman (Hu)
ClonalityMonoclonal
NCBI Gene Aliases16.3A5, EJ30, G344, HRF20, p18-20, MIRL, HRF-20, EJ16, 1F5, MIC11, MACIF, MAC-IP, MSK21, MEM43, EL32, MIN1, MIN2, MIN3
NCBI Full Gene NameCD59 molecule, complement regulatory protein
ApplicationsFCM, IF, FA
ImmunogenReacts with human CD59, a 20kDa glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 is widely distributed on cells in all tissues. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). This MAb recognizes CD59 transfected cells. It is useful for study on GPI-anchored proteins, PNH and CD59 functions
HostMouse
Clone193-27
Molecular WeightAntigen: 20kDa
IsotypeIgM kappa
TargetCD59
Format200ug/ml of Ab purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
Conjugate/TagUnconjugated
ConcentrationPurified Ab with BSA and Azide at 200ug/ml
Quantity0.1 mg