MyBioSource.com's Rabbit anti-human NEDD8 polyclonal Antibody(NEDD8) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunohistochemistry, and Western Blot. The Rabbit anti-human NEDD8 polyclonal Antibody(NEDD8) was generated using NEDD8 as the antigen and it reacts with Human, and Mouse.
Description
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins