The Rabbit anti-human Membrane cofactor protein polyclonal Antibody(CD46) from MyBioSource.com is a Rabbit Polyclonal antibody to CD46, and CD46 molecule. This antibody recognizes Human antigen. The Rabbit anti-human Membrane cofactor protein polyclonal Antibody(CD46) has been shown to work in the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46