The Rabbit anti-human Islet amyloid polypeptide polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to IAPP, and Islet Amyloid Polypeptide. This antibody recognizes Human antigen. The Rabbit anti-human Islet amyloid polypeptide polyclonal Antibody has been shown to work in the following applications: ELISA, and Immunohistochemistry.
Description
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the assosciation of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer s disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes