The Rabbit anti-human NLRP2 polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to NLRP2. This antibody recognizes Human antigen. The Rabbit anti-human NLRP2 polyclonal Antibody has been shown to work in the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases