HLA-DRB (MHC II) MBS438770 from MyBioSource.com

Product Specs
ItemHLA-DRB (MHC II)
CompanyMyBioSource.com
Price $275.00Supplier Page View Company Product Page
Catalog NumberMBS438770
ReactivityHuman (Hu)
ClonalityMonoclonal
NCBI Gene AliasesHLA-DRB, DRw10, SS1, HLA-DR1B, DRB1
NCBI Full Gene Namemajor histocompatibility complex, class II, DR beta 1
ApplicationsWB, FCM, IF, IHC-p
ImmunogenThis MAb reacts with the beta-chain of HLA-DR antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the SPM289 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts
HostMouse
CloneSPM289
Molecular WeightAntigen: ~28kDa (beta chain)
IsotypeIgG2b kappa
TargetHLA-DRB
Format200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
Conjugate/TagUnconjugated
ConcentrationPurified Ab with BSA and Azide at 200ug/ml
Quantity0.1 mg