CD22 / BL-CAM Antibody MBS439724 from MyBioSource.com

Product Specs
ItemCD22 / BL-CAM Antibody
CompanyMyBioSource.com
Price $275.00Supplier Page View Company Product Page
Catalog NumberMBS439724
Quantity0.1 mg
ApplicationsFunctional Studies, Flow Cytometry (FC/FACS), Immunofluorescence (IF)
ConcentrationPurified Ab with BSA and Azide at 200ug/ml
Conjugate/TagUnconjugated
Format200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
ReactivityHuman
TargetCD22 / BL-CAM
IsotypeIgG1 kappa
Molecular WeightAntigen: 130-140kDa
CloneFR10B4
HostMouse
ImmunogenRecognizes a protein of 130-140kDa, identified as CD22 (also known as BL-CAM). CD22 expression is restricted to normal and neoplastic B cells and is absent from other haemopoietic cell types. In B-cell ontogeny, CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. It is not expressed by plasma cells, CD22 is found highly expressed in follicular mantle and marginal zone B-cells, and while germinal center B-cells are relatively weak. CD22 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation
NCBI Full Gene NameCD22 molecule
NCBI Gene AliasesSIGLEC-2, SIGLEC2
ClonalityMonoclonal