The Rabbit Anti-Integrin alpha-IIb Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ITGA2B. This antibody recognizes Human antigen. The Rabbit Anti-Integrin alpha-IIb Antibody has been shown to work in the following applications: EIA, Immunoassay, and ELISA.
Description
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface