The Rabbit anti-human IL36RN polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to IL36RN. This antibody recognizes Human antigen. The Rabbit anti-human IL36RN polyclonal Antibody has been shown to work in the following applications: ELISA, and Immunohistochemistry.
Description
Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR