MyBioSource.com's RSPO3 Antibody (C-Term) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The RSPO3 Antibody (C-Term) was generated using R-Spondin 3, and RSPO3 as the antigen and it reacts with Human.
Description
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway