IRF-3 (D83B9) Rabbit mAb from Cell Signaling Technology

The IRF-3 (D83B9) Rabbit mAb has been shown to work in applications such as Western blotting and immunoprecipitation. For instance, it has been utilized at a dilution of 1:1,000 for Western blot analysis in studies investigating the cGAS-STING pathway and its role in various diseases, including cancer and autoimmune conditions.

Yes, the IRF-3 (D83B9) Rabbit mAb is reactive with multiple species, including human, mouse, rat, and non-human primates. This broad reactivity makes it suitable for comparative studies across different model organisms.

Yes, several studies have highlighted the role of IRF-3 in disease mechanisms. For example, research has shown that genetic deletion of IRF3 significantly reduced the activation of microglia and improved motor function in mouse models of Niemann-Pick disease type C, indicating its critical role in neuroinflammatory responses (chu2021).

The IRF-3 (D83B9) Rabbit mAb has been used to elucidate the mechanisms by which tumor suppressor proteins like p53 activate the cGAS-STING pathway, leading to the induction of type I interferons. This activation is crucial for enhancing antitumor immunity, as demonstrated in studies involving colorectal cancer treatments (ghosh2023; liang2024).