EGF Receptor (E746-A750del Specific) (D6B6) XP ® Rabbit mAb 2085S from Cell Signaling Technology

Product Specs
ItemEGF Receptor (E746-A750del Specific) (D6B6) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price Pricing Info Supplier Page View Company Product Page
Catalog Number2085S
Quantity100 µl
ApplicationsW, IP, IHC-P, IF-IC, FC-FP
ReactivityH
TargetEGFR (Glu746-Ala750) mutation
HostRabbit
NCBI Gene AliasesERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA
ClonalityMonoclonal
NCBI Full Gene Nameepidermal growth factor receptor
Research AreaRTK
IsotypeIgG
CloneD686
Molecular Weight175

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) BPTF Drives Gastric Cancer Resistance to EGFR Inhibitor by Epigenetically Regulating the C‐MYC/PLCG1/Perk AxisAdvanced ScienceOctober 20, 2023Fangyuan Li, Junxian Yu, Tao Pan, Haoran Feng, Jianfang Li, Beiqin Yu, Zhiyuan Fan, Qingqing Sang, Mengdi Chen, Mingde Zang, et al.(9100S), anti‐STAT3 (12640S), anti‐pSTAT3 (9145S), anti‐Akt (4691S), anti‐pAkt (4060S), anti‐EGFR (2085S), anti‐pEGFR (3777S) and HRP‐conjugated secondary antibodies (1:4000) (Cell Signaling Technology). After

(2) Cetuximab enhances radiosensitivity of esophageal squamous cell carcinoma cells by G2/M cycle arrest and DNA repair delay through inhibiting p‐EGFR and p‐ERKThoracic CancerJune 20, 2023Guifang Zhao, Liwen Feng, Ting Ye, Yanshen Liu, Li Fan, Chengzhi Ye, Jing Chenroom temperature and probed with primary antibodies γ‐H2AX (97 148, Cell Signaling Technology), EGFR (2085, Cell Signaling Technology), phospho‐EGFR (p‐EGFR) (4407, Cell Signaling Technology), protein kinase

(3) CAR-T cells targeting HLA-G as potent therapeutic strategy for EGFR-mutated and overexpressed oral canceriScienceMarch 17, 2023Lin YC, Hua CH, Lu HM, Huang SW, Chen Y, Tsai MH, Lin FY, Canoll P, Chiu SC, Huang WH, et al.ab5644,RRID: AB_305012" EGF Receptor (E746-A750del Specific) [D6B6],Cell Signaling Technology,"Cat# 2085,RRID: AB_1903953" EGFR Antibody [DH8.3] - EGFRvIII,Novus Biologicals,Cat# NBP2-50599 Phospho-p44/42

(4) Asparaginyl endopeptidase contributes to cetuximab resistance via MEK/ERK signaling in RAS wide-type metastatic colorectal cancerClinical and Translational OncologyJanuary 7, 2023Xiaojing Xu, Mengling Liu, Ke Peng, Yiyi Yu, Tianshu Liuovernight at 4 °C, AEP antibody (R&D Systems, AF2199) or EGFR antibody (Cell Signaling Technology, 2085), phosphor-EGFR antibody (Cell Signaling Technology, 3777), MEK1/2 (Cell Signaling Technology, 4694),

(5) A fluorogenic probe for predicting treatment response in non-small cell lung cancer with EGFR-activating mutationsNature communicationsNovember 14, 2022Deng H, Lei Q, Wang C, Wang Z, Chen H, Wang G, Yang N, Huang D, Yu Q, Yao M, et al.Signaling Technology (CST): EGFR wild-type (#4267), EGFR (L858R mutant, #3197), EGFR (E746-A750del, #2085), phospho-EGFR (Tyr1068, #3777), AKT (#4685), phospho-AKT (Ser473, #4060), ERK1/2 (Tyr1068, #4695),

(6) m(6)A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small-cell lung cancerCancer gene therapyOctober 1, 2022Tsuchiya K, Yoshimura K, Iwashita Y, Inoue Y, Ohta T, Watanabe H, Yamada H, Kawase A, Tanahashi M, Ogawa H, et al.(Ab124892, Abcam, Cambridge, UK) were diluted at 1:400, whereas those specific for EGFR E746-A750 deletion (#2085, D6B6, Cell Signaling Technology [CST], Danvers, MA, USA) and EGFR L858R mutant (#3197, 43B2, CST) were

(7) Examining the language demands of informed consent documents in patient recruitment to cancer trials using tools from corpus and computational linguisticsHealth: An Interdisciplinary Journal for the Social Study of Health, Illness and MedicineJuly 1, 2022Talia Isaacs, Jamie Murdoch, ZsÃ³fia DemjÃ©n, Fiona Stevensondescriptor,Log-likelihood,Log ratio,Examples,Raw,Per 1000,Raw,per 1000 PPY,2nd person personal pronoun (you),2085,3.56,4796,0.52,3929.9,2.79,You VM,"Modal auxiliary (can, will, would, etc.)",2486,4.25,12086,1.3,2214.23,1.71,"will

(8) Phospho-Aspirin (MDC-22) inhibits pancreatic cancer growth in patient-derived tumor xenografts and KPC mice by targeting EGFR: Enhanced efficacy in combination with irinotecanNeoplasiaFebruary 1, 2022Cecilia Rodriguez Lanzi, Ran Wei, Dingyuan Luo, Gerardo G. Mackenziep-ERK (Cat #4376), ERK (Cat #9102), cyclinD1 (Cat #2978), p-EGFRTyr1068 (Cat #3777) and EGFR (Cat #2085), using a 1:1,000 dilution of antibody in 5% (w/v) fat-free milk. β-actin (Cat #A1978) from Millipore-Sigma,

(9) Neurokinin-1 receptor promotes non-small cell lung cancer progression through transactivation of EGFRCell death & diseaseJanuary 10, 2022Zhang XW, Li L, Hu WQ, Hu MN, Tao Y, Hu H, Miao XK, Yang WL, Zhu Q, Mou LY.software and normalized to GAPDH. The primary antibodies anti-pEGFR (Try1068) (#3777), anti-EGFR (#2085), anti-pERK1/2 (#4370), anti-pAKT (#4060), anti-E-cadherin (#3195), and anti-Vimentin (#5741) were from

(10) Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid ModelsFrontiers in oncologyJanuary 1, 2022Lotsberg ML, Røsland GV, Rayford AJ, Dyrstad SE, Ekanger CT, Lu N, Frantz K, Stuhr LEB, Ditzel HJ, Thiery JP, et al.(Vimentin),EPR3776,ab92547,Abcam,1:100,ICC/IF TUBA1A (Alpha-tubulin),DM1A,ab7291,Abcam,1:1 000,ICC/IF EGFRdel (E746-A750del specific),D6B6,2085,CST,1:100,IHC-P/IF Antibodies for western blot (WB), Immunocytochemistry with immunofluorescent detection

(11) COL8A1 Promotes NSCLC Progression Through IFIT1/IFIT3-Mediated EGFR ActivationFrontiers in oncologyJanuary 1, 2022Zan X, Li S, Wei S, Gao L, Zhao L, Yan X, Zhao Y, Shi J, Wang Y, Liu R, et al.separated by SDS-PAGE, as described previously. Primary antibodies against p-EGFR (#3777S, CST), EGFR (#2085, CST), p-AKT (#4060, CST), AKT (#4821, CST), IFIT-1 (23247-1-AP, Proteintech), IFIT-3 (15201-1-AP, Proteintech),

(12) GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12iScienceNovember 19, 2021Bo Wei et al.AB_632280 anti-Ki-67,Santa Cruz Biotechnology,Cat# sc-23900; RRID: AB_627859 anti-EGFR,Cell Signaling Technology,Cat# 2085; RRID: AB_1903953 anti-pAkt (Ser473),Cell Signaling Technology,Cat# 4060; RRID: AB_2315049 anti-total

(13) A novel role of ADGRF1 (GPR110) in promoting cellular quiescence and chemoresistance in human epidermal growth factor receptor 2-positive breast cancerFASEB journal : official publication of the Federation of American Societies for Experimental BiologyJuly 1, 2021Abdulkareem NM, Bhat R, Qin L, Vasaikar S, Gopinathan A, Mitchell T, Shea MJ, Nanda S, Thangavel H, Zhang B, et al.(6B12) (catalog# 2243S, Cell Signaling), anti-EGF receptor/HER1 (E746-A750del Specific) (D6B6) (catalog# 2085S, Cell Signaling), anti-HER2/ErbB2 (29D8) (catalog# 2165S, Cell Signaling), anti-hADGRF1 (catalog# HPA038438,

(14) Autumn Warming Delays the Downregulation of Photosynthesis and Does Not Increase the Risk of Freezing Damage in Interior and Coastal Douglas-firFrontiers in Forests and Global ChangeJune 3, 2021Devin Noordermeer, Vera Marjorie Elauria Velasco, Ingo EnsmingerE) (m) LIT 50.54 −115.62 MEL 52.04 −122.33 PEM 50.32 TSO 49.78 Historical (1961–1990) Projected (2085) Tmax Tmin Tave P RH Tmax Tmin Tave P RH (◦ C) (◦ C) (◦ C) (mm) (%) (◦ C) (◦ C) (◦

(15) MicroRNA-181a suppresses norethisterone-promoted tumorigenesis of breast epithelial MCF10A cells through the PGRMC1/EGFR–PI3K/Akt/mTOR signaling pathwayTranslational OncologyJune 1, 2021Guiju Cai, Yuejiao Wang, Tahiri Houda, Chun Yang, Lijuan Wang, Muqing Gu, Alfred Mueck, Stephane Croteau, Xiangyan Ruan, Pierre Hardypurchased from Cell Signaling Technology, Inc., including anti-PGRMC1 (#13,856, l:1000), anti-EGFR (#2085, l:1000), anti-mechanistic target of rapamycin (mTOR) (#2983, l:1000), anti-phosphatase and tensin homolog

(16) circMTO1 sponges microRNA‑219a‑5p to enhance gallbladder cancer progression via the TGF‑β/Smad and EGFR pathwaysOncology LettersMay 27, 2021Pingfan Wang, Chenggang Zhou, Donghai Li, Dongsheng Zhang, Long Wei, Ying Dengagainst Smad2 (cat. no. 5339), Smad4 (cat. no. 46535), epidermal growth factor receptor (EGFR; cat. no. 2085), cleaved caspase-3 (cat. no. 25546-1-AP) and GAPDH (cat. no. 8884) overnight at 4°C (all 1:1,000 and

(17) Anti-tumoral activity of the Pan-HER (Sym013) antibody mixture in gemcitabine-resistant pancreatic cancer modelsmAbsApril 20, 2021Emilia Rabia et al.Antibodies against EGFR, HER2 and HER3 were from Cell Signaling Technology (Cell Signaling Technology, 2085, 2242, 4754). Cell lines and culture conditions for inducing gemcitabine resistance The BxPC3, SW1990,

(18) PRMT5 Promotes EMT Through Regulating Akt Activity in Human Lung CancerCell TransplantationApril 8, 2021Jianhao Huang, Yonghua Zheng, Xiao Zheng, Bao Qian, Qi Yin, Jingjing Lu, Han LeiCell Signaling Technology), phospho-Tyr-1068-EGFR (cat# 3777; Cell Signaling Technology) total EGFR (cat# 2085; Cell Signaling Technology), phospho-Ser2448-mTOR (cat# 5536; Cell Signaling Technology), total mTOR

(19) PRMT5 regulates colorectal cancer cell growth and EMT via EGFR/Akt/GSK3β signaling cascadesAging (Albany NY)February 15, 2021Yongrong Yan, Peipei Zhao, Zihuan Wang, Zhen Liu, Zhizhi Wang, Jinglan Zhang, Yanqing Ding, Xing Hua, Lina YuCell Signaling Technology), phospho-Tyr-1068-EGFR (cat# 3777; Cell Signaling Technology) total EGFR (cat# 2085; Cell Signaling Technology), β-catenin (cat# 8480; Cell Signaling Technology) and β-tubulin (cat# 5666;

(20) LncRNA TINCR favors tumorigenesis via STAT3-TINCR-EGFR-feedback loop by recruiting DNMT1 and acting as a competing endogenous RNA in human breast cancerCell death & diseaseJanuary 14, 2021Wang Q, Liu J, You Z, Yin Y, Liu L, Kang Y, Li S, Ning S, Li H, Gong Y, et al.membranes were immunoblotted with primary antibodies from Cell Signaling Technology (CST) against EGFR (#2085), p-EGFR (#11862), JAK2 (Catalog #: 3230), p-JAK2 (Catalog #: 3771), STAT3 (Catalog #: 9139), and p-STAT3

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9/29/2020Nice EGFR Antibody Sachin SamuchiwalEGFR is a receptor for epithelial growth factor that initiates cell proliferation, migration and invasion in cancer cells. I tested this antibody for determining the expression of EGFR in human cancer... Read Review

EGF Receptor (E746-A750del Specific) (D6B6) XP ® Rabbit mAb

EGF Receptor (E746-A750del Specific) (D6B6) XP ® Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

Citations (64)

Reviews

EGF Receptor (E746-A750del Specific) (D6B6) XP ® Rabbit mAb from Cell Signaling Technology

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