GLI1 (C68H3) Rabbit mAb 3538S from Cell Signaling Technology

Product Specs
ItemGLI1 (C68H3) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number3538S
Quantity100 µl
ApplicationsW, IP
ReactivityH
TargetGLI1
HostRabbit
NCBI Gene AliasesGLI, PAPA8, PPD1
ClonalityMonoclonal
NCBI Full Gene NameGLI family zinc finger 1
Research AreaDevelopmental Biology
IsotypeIgG
CloneC68H3
Molecular Weight160

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Adipose-Derived Stem Cell Treatment Induces Early-Term Hes1 Upregulation in a Sox9- and Notch1-Independent Manner in a Rat Model of Bile Duct LigationBiomedicinesMarch 13, 2026Basri Satılmış, Egemen Çiçek, Serdar Karakaş, Koray Kutlutürk, Elif Kayhan, Mehmet Gül, Emrah Otan, Tevfik Tolga Şahin, Sezai YılmazMA, USA, 8480), YAP/TAZ (Cell Signaling, 8418), Notch1 (Cell Signaling, 3608), Gli1 (Cell Signaling, 3538), Sox9 (Cell Signaling, 82630), Hes1 (Cell Signaling, 11988), and β-actin (Cell Signaling, 4970) and

(2) Liver-derived Indian Hedgehog (Ihh) couples fast-feed transition to thermogenic and metabolic homeostasisMolecular MetabolismFebruary 26, 2026Raffaele Teperino, Marketa Adamová, Shefa’ Muneer Aljabali, Shruta Pai, Raffaele Gerlini, Irene Paez-Perez, Madlen Matz-Soja, Steffen Heyne, Adelheid Lempradl, Maria Felicia Basilicata, et al.anti-IHH - abcam Cat #ab39634 (1:1000). Rabbit monoclonal anti-Gli1 - Cell Signalling Technology Cat. #3538 (1:1000). Anti-H3K27me3 - Gift from Thomas Jenuwein already used in [29]. Rabbit Polyclonal anti-Ucp1

(3) Hyperthermia Inhibits Growth and Stemness of Esophageal Squamous Cell Carcinoma Cells Through Promoting Degradation of GLI1Stem Cells InternationalDecember 11, 2025Hui Qin, Xiaole Li, Shichao Duan, Shenglei Li, Minghua RenWestern blotting. 2.5. Antibodies The antibodies information were as follows: GLI1 (1:1000, Cell Signaling Technology, 3538), OCT4 (1:1000, Proteintech, 11263‐1‐AP), SOX2 (1:1000, ProteinTech, 1‐1064‐1‐AP), NANOG (1:1000, Proteintech,

(4) Nuclear VAV1 increases GLI1-dependent transcription in pancreatic cancer cellsJournal of Biological ChemistryNovember 26, 2025Brooke R. Tader, Luciana L. Almada, Murat Toruner, Kayla C. LaRue-Nolan, David L. Marks, Ashley N. Sigafoos, Laura Hilario-Garcia, Vladimir G. Gainullin, Daniel D. Billadeau, Martin E. Fernandez-Zapico(1:1000 dilution; Novus, catalog no.: NBP1-06712SS), GLI1 (1:1000 dilution; Cell Signaling, catalog no.: 3538S), BCL2 (1:500 dilution; BD Biosciences, catalog no.: 610538), HA (1:1000 dilution; Cell Signaling, catalog

(5) Germline–Somatic Liaison Dictates Cancer Subtypes via de novo Steroid BiosynthesisCancer DiscoveryOctober 6, 2025Paola Gasperini, Alessandro Alaimo, Blerta Stringa, Yoon-Mi Chung, Yari Ciani, Francesca Lorenzin, Giulia Fracassi, Yanis Zekri, Francesco Orlando, Orsetta Quaini, et al.(Cell Signaling Technology, cat. # 5153, RRID: AB_10691711), GLI1 (Cell Signaling Technology, cat. # 3538, RRID: AB_1903989), GLI3 (Abcam, cat. # ab181130, RRID: AB_2732891), PTCH1 (Abcam, cat. # ab53715, RRID:

(6) Molecular characteristics and cancer immunity of LRP1B and its relationship with the Hedgehog signaling pathway in colorectal cancerFrontiers in ImmunologyMarch 18, 2025Yuan Liu, Yang Zhong, Yaodong Sang, Siqiang Zhu, Kang Xu, Xingyu Zhu, Xiaoling Cui, Xinyu Liu, Xiaohan Wang, Hao Chen, et al.Cell Signaling Technology, USA), SUFU (1:1,000, 2520T, Cell Signaling Technology, USA), GLI1 (1:1,000, 3538T, Cell Signaling Technology, USA), CHEK2 (1:1,000, 13954-1-AP, Proteintech, Chicago, USA), E2F1 (1:200,

(7) COLEC10: A potential tumor suppressor and prognostic biomarker in hepatocellular carcinoma through modulation of EMT and PI3K-AKT pathwaysOpen Life SciFebruary 26, 2025Rui-Sheng Ke, Yun Dai, Yan-ling Tu, Zhao-Hui Liu, Kun-Zhai Huang, Fu-Xing Zhangantibodies used in this study were N-cadherin (#13116T), E-cadherin (#14472S), Vimentin (#5741T), GLI1 (#3538T), SHH (#2207T), PTCH1 (#2468T), SMO (#92981S), phospho-AKT (#2920S), PI3K (#4257), AKT (#4060T), and

(8) Non-cell-autonomous regulation of mTORC2 by Hedgehog signaling maintains lipid homeostasisCell ReportsJanuary 28, 2025Kylie R. VanDerMolen, Martin A. Newman, Peter C. Breen, Yunjing Gao, Laura A. Huff, Robert H. Dowen#9234), anti-S6K (Cell Signaling Technology, #9202), anti-GLI1 clone C68H3 (Cell Signaling Technology, #3538), anti-GLI1 clone L42B10 (Cell Signaling Technology, #2643), anti-Rictor (Cell Signaling Technology,

(9) GANT61 surmounts drug resistance of ADR by upregulating lysosome activities and reducing BCL2 expression in HL-60/ADR cellsCancer Cell InternationalDecember 26, 2024Cheng Zhou, Liang Zhao, Ming Zhou, Chao Wu, Guanghua Liu, Jiangwen Long, Yuanxiang Shi, Can Liusystem (Bio-Rad). The antibody dilutions used were as follows: GLI1 1:1000 (Cell Signaling Technology, 3538, USA), BCL2 1:1000 (Wanleibio, WL01556, Shenyang, China), Bax 1:1000 (Wanleibio, WL01637, Shenyang,

(10) CD56 polysialylation promotes the tumorigenesis and progression via the Hedgehog and Wnt/β-catenin signaling pathways in clear cell renal cell carcinomaCancer cell internationalDecember 12, 2023Jian Y, Zhang L, Gong L, Ding M, Sun X, Yu X, Lv S, Li J, Yang D, Wang S.Cell Signaling Technology, #2470), SHH (1:1000, Cell Signaling Technology, #2207), GLi1 (1:400, Cell Signaling Technology, #3538), SMO (1:1000, Cell Signaling Technology, #92981), β-catenin (1:5000, Proteintech, 66379-1-Ig), c-Myc

(11) PKNOX1 acts as a transcription factor of DHH and promotes the progression of stomach adenocarcinoma by regulating the Hedgehog signalling pathwayInternational Journal of Immunopathology and PharmacologyDecember 1, 2023Bing Liu, Siwei Zhao, Liqing LiuD2 (CCND2, #3741, Cell Signaling Technology, USA), anti-glioma-associated oncogene protein 1 (GLI1, #3538, Cell Signaling Technology, USA), smoothened (SMO, A3274, Abclonal, US), N-cadherin (A0433, Abclonal,

(12) Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17Science AdvancesOctober 27, 2023Yalong Wang, Ruoyu Lou, Zhe Zhang, Chuyu Xiao, Shicheng Yu, Siting Wei, Yuan Liu, Wei Fu, Baojie Li, Ye-Guang Chenanti–p-Smad1/5 (1:100; 9516, CST), mouse anti-Ki67 (1:200; 9449, CST), and rabbit anti-Gli1 (1:80; 3538, CST). FACS analysis For stromal cells isolated from mice, dissociated cells were passed through 40-μm

(13) CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesiseLifeSeptember 22, 2023Bo Wang, Zheyong Liang, Tan Tan, Miao Zhang, Yina Jiang, Yangyang Shang, Xiaoqian Gao, Shaoran Song, Ruiqi Wang, He Chen, et al.UK, ab279653), phospho-histone H3 (Abcam, ab267372), cleaved caspase 3 (CST, USA, #9661), GLI1 (CST, #3538), and β-catenin (CST, #8480). The following steps used biotin-streptavidin HRP detection kits (ZSGB-BIO,

(14) SUFU promotes GLI activity in a Hedgehog-independent manner in pancreatic cancerThe Biochemical journalAugust 16, 2023Paradise BD, Gainullin VG, Almada LL, Sigafoos AN, Sen S, Vera RE, Raja Arul GL, Toruner M, Pease DR, Gonzalez AL, et al.Millipore Sigma), anti-GAPDH (GTX627408, GeneTex, CA, USA), anti-Lamin A (ab26300, Abcam), anti-GLI1 (3538, Cell Signaling Technology, MA, USA), anti-α-Tubulin (T9026, Sigma-Aldrich), anti-FLAG (F1804, Sigma-Aldrich),

(15) Baicalin attenuates dexamethasone-induced apoptosis of bone marrow mesenchymal stem cells by activating the hedgehog signaling pathwayChinese Medical JournalAugust 5, 2023Bin Jia, Yaping Jiang, Yao Yao, Yingxing Xu, Yingzhen Wang, Tao Lianti-human sonic hedgehog (SHH, 2207T), suppressor of fused (SUFU; 2522S), zinc finger protein GLI-1 (GLI-1; 3538T), apoptosis regulator BAX (Bax; 5023T), B-cell lymphoma 2 (Bcl-2; 4223T), caspase-3 (14220T), and cleaved

(16) MALAT1 functions as a transcriptional promoter of MALAT1::GLI1 fusion for truncated GLI1 protein expression in cancerBMC CancerMay 10, 2023Taiji Hamada, Michiyo Higashi, Seiya Yokoyama, Toshiaki Akahane, Masanori Hisaoka, Hirotsugu Noguchi, Tatsuhiko Furukawa, Akihide Tanimototemperature. The antibodies used in this study (all from CST, except for anti-FLAG) were anti-GLI1 (#3538), anti-Myc-tag (#2278), anti-SUFU (#2522), anti-β-actin (#4970), anti-MEK1 (#4694), anti-histone deacetylase

(17) Multiplatform molecular profiling uncovers two subgroups of malignant peripheral nerve sheath tumors with distinct therapeutic vulnerabilitiesNature communicationsMay 10, 2023Suppiah S, Mansouri S, Mamatjan Y, Liu JC, Bhunia MM, Patil V, Rath P, Mehani B, Heir P, Bunda S, et al.#8457S, 1:10), PTCH1 (Cell Signaling Technologies #2468, 1:10), GLI1 (Cell Signaling Technologies #3538, 1:10). Anchorage independent growth assay 6-well plates (Corning) were prepared with bottom agar

(18) The Hedgehog/GLI signaling pathway activates transcription of Slug (Snail2) in melanoma cellsOncology reportsApril 1, 2023Horák P, Kreisingerová K, Réda J, Ondrušová L, Balko J, Vachtenheim J Jr, Žáková P, Vachtenheim J.extracts were then directly utilized. Primary antibodies for western blotting were: GLI1 (cat. no. 3538; Cell Signaling Technology, Inc.), GLI2 (cat. no. TX46056; GeneTex, Inc.), and GLI3 (cat. no. AF3690;

(19) Drug Repurposing Flubendazole to Suppress Tumorigenicity via PCSK9-dependent Inhibition and Potentiate Lenvatinib Therapy for Hepatocellular CarcinomaInternational journal of biological sciencesJanuary 1, 2023Jin W, Yu J, Su Y, Lin H, Liu T, Chen J, Ge C, Zhao F, Geng Q, Mao L, et al.(10981) were purchased from MedChem Express (New Jersey, USA). Antibodies against PCSK9 (85813) and GLI1 (3538) used for western blotting were obtained from Cell Signaling Technology (Massachusetts, USA). The monoclonal

(20) Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated ciliaNature biomedical engineeringApril 1, 2022Cruz NM, Reddy R, McFaline-Figueroa JL, Tran C, Fu H, Freedman BS.(Cell Signaling 18634), IFT88 (Proteintech 13967–1-AP), ARL13B (Proteintech 17711–1-AP), GLI1 (Cell Signaling 3538), GLI2 (Abcam ab26056), PTCH1 (Cell Signaling 8358), ALIX (Cell Signaling 2171), ANXA5 (Cell Signaling

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GLI1 (C68H3) Rabbit mAb

GLI1 (C68H3) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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GLI1 (C68H3) Rabbit mAb from Cell Signaling Technology

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