GoInVivo™ Purified Rat IgG2b, κ Isotype Ctrl 400663 from BioLegend

Product Specs
ItemGoInVivo™ Purified Rat IgG2b, κ Isotype Ctrl
CompanyBioLegend
Price $4,455.00Supplier Page View Company Product Page
Catalog Number400663
Quantity100 mg
ApplicationsFC - Quality tested, ICFC, ICC, IHC, IP, WB, FA - Reported in the literature, not verified in house
Conjugate/TagUnconjugated, Super Low Endotoxin Azide Free
Format0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative
IsotypeRat IgG2b, kappa
CloneRTK4530
HostRat
ImmunogenTrinitrophenol + KLH
ClonalityMonoclonal
Antibody TypeIsotype Control
ConcentrationThe antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL

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BioLegend

8999 BioLegend Way

San Diego, California 92121

United States

Phone: 1-877-246-5343 Toll-Free, USA & Canada
1-858-768-5800 International
Fax: 1-877-455-9587

Company Profile

Website: biolegend.com

(1) Lymph node macrophage-targeted interferon alpha boosts anticancer immune responses by regulating CD169-positive phenotype of macrophagesMol CancerMay 3, 2025Ryo Fukuda, Yukio Fujiwara, Hitoshi Maeda, Cheng Pan, Yuki Minayoshi, Hiromu Yano, Yuki Mizuta, Mei Takano, Rin Yamada, Yoichi Saito, et al.therapy, the mice were treated intraperitoneally with isotype control antibodies (200 µg; BioLegend, 400667) and anti-PD-L1 antibodies (200 µg; BioLegend, 124329) on the 10th and 13th days after tumor inoculation

(2) Immune-checkpoint-inhibitor therapy directed against PD-L1 is tolerated in the heart without manifestation of cardiac inflammation in a preclinical reversible melanoma mouse modelFront Mol MedJanuary 6, 2025Caroline Schoenherr, Stefan Pietzsch, Cristina Barca, Franziska E. Müller, Frauke S. Bahr, Martina Kasten, Andre Zeug, Sergej Erschow, Christine S. Falk, Evgeni Ponimaskin, et al.124328, BioLegend) or corresponding isotype control (Ctrl, GolnVivo purified rat IgG2b,k isotype Ctrl, no 400666, BioLegend) were applied i.p. at day 7, 10, and 13 after tumor cell or PBS injection for a total of

(3) Regulation of pulmonary plasma cell responses during secondary infection with influenza virusThe Journal of experimental medicineJuly 1, 2024MacLean AJ, Bonifacio JPPL, Oram SL, Mohsen MO, Bachmann MF, Arnon TI.BioXCell), anti-CD8β antibodies (Clone 53-5.8, BE0223; BioXCell), or control rat IgGb (Clone RTK4530, cat. 400667; Biolegend). Antibodies were injected into memory phase mice 3 days prior to rechallenge via two routes

(4) Circadian control of tumor immunosuppression affects efficacy of immune checkpoint blockadeNature immunologyJuly 1, 2024Fortin BM, Pfeiffer SM, Insua-Rodríguez J, Alshetaiwi H, Moshensky A, Song WA, Mahieu AL, Chun SK, Lewis AN, Hsu A, et al.Two tumors were injected per mouse 1cm off the midline in both sides of the abdomen. IgG (BioLegend, 400668) or anti-PD-L1 (BioLegend, 124329) were administered every 2–3 days (200 μg per mouse) for a total of

(5) Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lungNat CommunMarch 30, 2024Patrick J. Dörner, Harithaa Anandakumar, Ivo Röwekamp, Facundo Fiocca Vernengo, Belén Millet Pascual-Leone, Marta Krzanowski, Josua Sellmaier, Ulrike Brüning, Raphaela Fritsche-Guenther, Lennart Pfannkuch, et al.CCR2 (clone MC-21, gifted by Matthias Mack) or corresponding isotype control IgG2b (clone RTK4530; #400666, BioLegend) intraperitoneally immediately at the time of infection. Bone marrow isolation Mice were

(6) Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channelsJournal of extracellular vesiclesDecember 1, 2022Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, et al.USA",124328, "GoInVivoTM Purified Rat IgG2b, κ Isotype Ctrl Antibody","BioLegend, San Diego, CA, USA",400666, Flow cytometry analysis,,, Anti‐Mouse CD16/32 Antibody,"BioLegend, San Diego, CA, USA",101303, FITC

(7) In vitro and in vivo functions of T cells produced in complemented thymi of chimeric mice generated by blastocyst complementationScientific reportsFebruary 25, 2022Yamazaki K, Kubara K, Ishii S, Li P, Dairiki R, Hihara T, Ishizuka Y, Izumi Y, Kumai M, Kamisako T, et al.injected with control IgG (50 μg/100 μL/head; GoInVivo Purified Rat IgG2b, κ, clone RTK4530, catalog no. 400666, BioLegend) (n = 5 for B6; n = 4 for chimeras) or anti-PD-L1 antibody (50 μg/100 μL/head; GoInVivo Purified

(8) PDL-1 Blockade Prevents T Cell Exhaustion, Inhibits Autophagy, and Promotes Clearance of Leishmania donovaniInfection and immunityJune 1, 2018Habib S, El Andaloussi A, Elmasry K, Handoussa A, Azab M, Elsawey A, Al-Hendy A, Ismail N.antibodies. Anti-mouse PDL-1 antibody (CD274) and rat IgG2b isotype control antibodies (124328 and 400664; BioLegend, San Diego, CA, USA) were administered intraperitoneally at 400 ␮g/mouse in four divided

(9) Deficiency of Dab2 (Disabled Homolog 2) in Myeloid Cells Exacerbates Inflammation in Liver and Atherosclerotic Plaques in LDLR (Low-Density Lipoprotein Receptor)-Null Mice-Brief ReportArteriosclerosis, thrombosis, and vascular biologyMay 1, 2018Adamson SE, Polanowska-Grabowska R, Marqueen K, Griffiths R, Angdisen J, Breevoort SR, Schulman IG, Leitinger N.(active/cleaved; NB 100-56113, Novus Biologicals). Rat IgG2a control (CLCR2A00, Cedarlane), rat IgG2b (RTK4530, #400666, BioLegend) and rabbit polyclonal IgG (NBP2-24891, Novus Biologicals) were used as isotype controls.

(10) Interleukin-19 increases angiogenesis in ischemic hind limbs by direct effects on both endothelial cells and macrophage polarizationJournal of molecular and cellular cardiologyFebruary 1, 2015Richards J, Gabunia K, Kelemen SE, Kako F, Choi ET, Autieri MV.

(11) Myeloid-derived suppressor cells impair alveolar macrophages through PD-1 receptor ligation during Pneumocystis pneumoniaInfection and immunityFebruary 1, 2015Lei GS, Zhang C, Lee CH.

(12) ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10-/- miceJournal of leukocyte biologyFebruary 1, 2010Schaefer JS, Montufar-Solis D, Vigneswaran N, Klein JR.

(13) Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activationBloodJune 4, 2009Yi H, Yu X, Gao P, Wang Y, Baek SH, Chen X, Kim HL, Subjeck JR, Wang XY.

(14) Microbial carbohydrate depolymerization by antigen-presenting cells: deamination prior to presentation by the MHCII pathwayProceedings of the National Academy of Sciences of the United States of AmericaApril 1, 2008Duan J, Avci FY, Kasper DL.

(15) Brain catecholamines and catecholamine-synthesizing enzymes in renovascular hypertension in the ratClinical science and molecular medicine. SupplementDecember 1, 1978M A Petty, J L Reid

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GoInVivo™ Purified Rat IgG2b, κ Isotype Ctrl from BioLegend

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GoInVivo™ Purified Rat IgG2b, κ Isotype Ctrl from BioLegend

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