Fig 2: The impact of NA and rhynchophylline on melanogenesis. A GSEA of melanogenesis in NA-treated A2058 cells; B Relative expression level of melanocyte stem cells related genes in NA alone or NA-rhynchophylline treated A2058 cells; C A2058 and B16F10 cells treated with different concentrations of NA and rhynchophylline were subjected to western blot with anti-MITF and anti-DCT antibody. NA100: 100 µM NA treated; NA500: 500 µM NA treated; NA100-Rh: 100 µM NA and 100 µM rhynchophylline treated; NA500-Rh: 500 µM NA and 100 µM rhynchophylline treated

Fig 3: PFE inhibited the expression of MITF. (A) The proteins' expression of MITF. (B) The grayscale value of the expression of MITF when compared to the forskolin‐stimulated group. Results were presented as the mean ± SD (n = 3; **p < 0.01, ***p < 0.001).