The MDM2 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Hdm2, MDM2, and MDM2 proto-oncogene. This antibody recognizes Human, Mouse, and Rat antigen. The MDM2 Polyclonal Antibody has been shown to work in the following applications: Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 (1). Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53 (2-4). Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53 (3)