Mouse Anti-Human TLR2-APC Antibody MBS670140 from MyBioSource.com

Product Specs
ItemMouse Anti-Human TLR2-APC Antibody
CompanyMyBioSource.com
Price $455.00Supplier Page View Company Product Page
Catalog NumberMBS670140
Quantity100 Tests
ApplicationsFlow Cytometry
Conjugate/TagAllophycocyanin (APC)
FormatAllophycocyanin (APC) Conjugate
ReactivityHuman
TargetToll-like Receptor 2 (TLR2)
IsotypeIgG2a
Clone2B4A1
HostMouse
ImmunogenHuman Toll-like Receptor 2 (TLR2)
The Toll-like receptor (TLR) family is comprised of Type I transmembrane proteins characterized by an extracellular leucine-rich domain and a cytoplasmic tail that contains a conserved region call the Toll/IL-1 (TIR) domain. First discovered in Drosophila, TLRs recognize specific molecular patterns that are present in microbial components and respond to these components in order eliminate or limit invading microbes. To date, ten mammalian homologs of TLRs have been described. Activation of TLR2 leads to the initiation of apoptosis and the activation of the NK- kappa B pathway by the adaptor molecule MyD88. TLR2 recognizes and is activated by components from a broad variety of microorganisms including lipoproteins from Gram-negative bacteria, Mycoplasma, spirochetes, peptidoglycan and LTAs from Gram-positive bacteria, lipoarabinomannan from mycobacteria, glycoinositolphospholipids, phenolsoluble modulin, zymosan from yeast and neisserial porins. TLR2 has been reported to functionally associate with TLR1 and TLR6 in order to recognize various lipopeptides.1-16
ClonalityMonoclonal