MyBioSource.com's RAT ANTI MOUSE CD49d:Low Endotoxin is a Rat monoclonal antibody. The RAT ANTI MOUSE CD49d:Low Endotoxin Antibody was generated using CD49d, Integrin alpha 4, and ITGA4 as the antigen. It reacts with Mouse. This antibody has been shown to work in applications such as: Flow Cytometry, Functional Assay, Immunohistochemistry, and Immunoprecipitation.
Description
Rat anti Mouse CD49d monoclonal antibody, clone PS/2 recognizes murine alpha 4 integrin (CD49d), a ~150kDa single pass type I membrane glycoprotein that can associate with either beta 1 integrin (CD29) or beta 7 integrin to form heterodimers CD49d/CD29 (VLA-4) and alpha4/beta7 (LPAM-1) respectively (Holzmann et al. 1989). CD49d is expressed on most lymphocytes, granulocytes, monocytes and thymocytes. The primary ligands for CD49d are CD106 (VCAM-1), fibronectin and MAdCAM-1 (Sheppard et al. 1994). Clone PS/2 has also been reported to block the binding of CD49d to its ligands (Andrew et al. 1994)