The ADAP Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ADAP, FYB, and p120/130. This antibody recognizes Human, and Mouse antigen. The ADAP Antibody has been shown to work in the following applications: ELISA, Immunocytochemistry, and Western Blot.
Description
The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kB family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist