MyBioSource.com's CCL4 Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Western Blot. The CCL4 Polyclonal Antibody was generated using ACT2, CCL4, CCL4L1, and MIP1B as the antigen and it reacts with Human.
Description
Chemokines are members of a superfamily of small inducible, secreted, pro-inflammatory cytokines. Members of the chemokine family exhibit 20 to 50% homology in their predicted amino acid sequences and are divided into four subfamilies. In C-C (or b) subfamily, the first two cysteines are adjacent. C-C chemokines are chemoattractants and activators for monocytes and T cells. C-C subfamily members include macrophage inflammatory protein (MIP)-1¥, MIP-1ˆ«, MIP-2, MIP-3¥, MIP-3ˆ«, MIP-4, HCC-1, MIP-5 (or HCC-2), RANTES, MCP-1/2/3 (and the murine homologs JE and MARC), I-309, murine C10 and TCA3. Research has shown that MIP-1ˆ« is more selective than MIP-1¥, primarily attracting CD4+ T lymphocytes, with a preference for T cells of the naive phenotype. MIP-1¥ is a more potent lymphocyte chemoattractant than MIP-1ˆ« and exhibits a broader range of chemoattractant specificities. It has been suggested that CD8+ T lymphocytes are involved in the control of HIV infection in vivo by the release of HIV-suppressive factors (HIV-SF). MIP-1¥ has been identified as one of the major HIV-SFs produced by CD8+ T cells, along with MIP-1ˆ« and RANTES. Recombinant human MIP-1¥ acts as an inhibitor of different strains of HIV-1, HIV-2 and SIV infection in a dose-dependent manner