The ZAP70 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to MUR, ZAP-70, and ZAP70. This antibody recognizes Human, Mouse, and Rat antigen. The ZAP70 Polyclonal Antibody has been shown to work in the following applications: Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
The Syk family protein tyrosine kinase Zap-70 is expressed in T and NK cells and plays a critical role in mediating T cell activation in response to T cell receptor (TCR) engagement (1). Following TCR engagement, Zap-70 is rapidly phosphorylated on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck (2-6). Tyrosine phosphorylation correlates with increased Zap-70 kinase activity and downstream signaling events. Expression of Zap-70 is correlated with disease progression and survival in patients with chronic lymphocytic leukemia (7,8)