The TP63 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to KET, p73H, RHS, TP63, Trp63, and tumor protein p63. This antibody recognizes Human, Mouse, and Rat antigen. The TP63 Polyclonal Antibody has been shown to work in the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins