MyBioSource.com's CSNK2A2 Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunofluorescence, Immunohistochemistry, and Western Blot. The CSNK2A2 Polyclonal Antibody was generated using CK2A2, and CSNK2A2 as the antigen and it reacts with Human, Mouse, and Rat.
Description
Casein kinase I (also designated CKI) and casein kinase II (CKII) compose a family of serine/threonine protein kinases which are present in all eukaryotes examined to date. Casein kinase I family members, which include casein kinase I¥, I©, Iˆ‚ and Ie, have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. CKII is usually expressed as a tetrameric complex consisting of either an ¥2ˆ«2 or an ¥¥'ˆ«2 structure. The a catalytic subunit is stimulated by the ˆ« regulatory subunit, which undergoes autophosphorylation. Casein kinase II activity is high in the cytosol and nucleus of proliferating and differentiating cells. Casein kinase II is known to phosphorylate more than 100 different substrates including nuclear oncoproteins, transcription factors and enzymes involved in DNA metabolism