MyBioSource.com's mAb anti-human Raf-1 is a Mouse monoclonal antibody. The mAb anti-human Raf-1 Antibody was generated using RAF1 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Western Blot.
Description
Raf-1 is a serine/threonine protein kinase in the mitogen-activated protein kinase (MAPK) pathway. When extracellular signal binds to the G-protein coupled membrane receptor, Ras binds to GTP and phosphorylates Raf. The activated Raf phosphorylates MAPK kinase, which consecutively, activates MAPK. MAPK triggers the transcription of a wide spectrum of genes involved with cell growth and differentiation by activating transcription factors such as C-myc and CREB. MAPK also regulates translation by phosphorylating RSK, a ribosomal protein 6S kinase.
Gene for Raf-1 is located on chromosome 3. The mutations on Raf-1 may relate to some rare but severe diseases such as Noonan syndrome and Leopard syndrome