MyBioSource.com's MOUSE ANTI HUMAN DECTIN-1:RPE is a Mouse monoclonal antibody. The MOUSE ANTI HUMAN DECTIN-1:RPE Antibody was generated using Beta Glucan Receptor, CLEC7A, and Dectin 1 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Flow Cytometry.
Description
Mouse anti Human Dectin-1 antibody, clone GE2 recognizes human Dectin-1, also known as beta-glucan receptor (betaGR), a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (betaGR-A and betaGR-B) and several minor isoforms. betaGR-A and betaGR-B differs by the presence and absence, respectively, of a stalk region. Mouse anti Human Dectin-1 antibody, clone GE2recognizes both of these isoforms. Clone GE2 could be used to inhibit receptor function