The PCNA Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PCNA, PCNAR, and proliferating cell nuclear antigen. This antibody recognizes Human, Mouse, and Rat antigen. The PCNA Polyclonal Antibody has been shown to work in the following applications: Immunofluorescence, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Proliferating cell nuclear antigen (PCNA) is a member of the DNA sliding clamp family of proteins that assist in DNA replication (1). Crystal structure data suggests that a PCNA homotrimer ring can encircle and slide along the DNA double helix (2). Multiple proteins involved in DNA replication, DNA repair, and cell cycle control bind to PCNA rather than directly associating with DNA, thus facilitating fast processing of DNA (reviewed in 3). PCNA protein expression is a well-accepted marker of proliferation and PCNA (PC10) Mouse mAb has been used to assess PCNA levels in hundreds of scientific studies