The USP2 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to USP2. This antibody recognizes Human, Mouse, and Rat antigen. The USP2 Polyclonal Antibody has been shown to work in the following applications: ELISA, and Immunohistochemistry.
Description
This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified