The HCLS1 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to HCLS1. This antibody recognizes Human, Mouse, and Rat antigen. The HCLS1 Polyclonal Antibody has been shown to work in the following applications: Immunohistochemistry, and Western Blot.
Description
HS1 (HCLS1, LckBP1, p75) is a protein kinase substrate that is expressed only in tissues and cells of hematopoietic origin (1,2). HS1 contains four cortactin repeats and a single SH3 domain (2). This intracellular protein is phosphorylated following immune receptor activation, which promotes recruitment of HS1 to the immune synapse (3-5). Phosphorylation of HS1 is required to regulate actin dynamics and provide docking sites for many other signaling molecules, such as Vav1 and PLCgamma1 (6). HS1 also plays an important role in platelet activation (7)