The MLST8 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to LST8. This antibody recognizes Human, Mouse, and Rat antigen. The MLST8 Polyclonal Antibody has been shown to work in the following applications: Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian Target of Rapamycin (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals (1). mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GbetaL, and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GbetaL, and rictor (1). GbetaL associates with the kinase domain of mTOR and stimulates mTOR kinase activity (2). A reduction in GbetaL expression has been shown to decrease in vivo phosphorylation of S6K1 (2)