CD171/ NCAM-L1 Antibody MBS438494 from MyBioSource.com

Product Specs
ItemCD171/ NCAM-L1 Antibody
CompanyMyBioSource.com
Price $275.00Supplier Page View Company Product Page
Catalog NumberMBS438494
Quantity0.1 mg
ApplicationsELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB), Immunohistology (IH)
Conjugate/TagUnconjugated
ReactivityHuman
TargetCD171
IsotypeIgG1 kappa
Molecular Weight220-240kDa
CloneSPM275
HostMouse
ImmunogenRecognizes a cell surface protein of 220-240kDa, identified as L1 cell adhesion molecule. The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. This MAb is useful in the identification of primitive neuroectodermal tumors. It binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain
NCBI Full Gene NameL1 cell adhesion molecule
NCBI Gene AliasesSPG1, S10, N-CAML1, MASA, MIC5, CD171, HSAS1, CAML1, N-CAM-L1, NCAM-L1, HSAS
ClonalityMonoclonal