MyBioSource.com's CD33 Antibody is a Mouse monoclonal antibody. The CD33 Antibody was generated using CD33, and SIGLEC3 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: ELISA, Immunofluorescence, and Western Blot.
Description
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro)