The MOUSE ANTI HUMAN CD221:RPE Antibody from MyBioSource.com is a Mouse Monoclonal antibody to CD221, hyft, IGF1R, igf1ra, and IGFR. This antibody recognizes Human antigen. The MOUSE ANTI HUMAN CD221:RPE Antibody has been shown to work in the following applications: Flow Cytometry.
Description
Mouse anti Human CD221 antibody, clone 1H7 recognizes human CD221, a 155kD receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. Clone 1H7 recognizes an epitope in the alpha subunits of CD221, demonstrated by Western blotting (Li et al.1993). CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin. The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signalling proteins. Clone 1H7 is reported to partically block binding of IGF-I and IGF-II to CD221 (Li et al.1993)