The SH2B2 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to SH2B2. This antibody recognizes Human, Mouse, and Rat antigen. The SH2B2 Polyclonal Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Immunohistochemistry.
Description
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway