MyBioSource.com's MLST8 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Western Blot. The MLST8 Antibody was generated using LST8 as the antigen and it reacts with Human, Mouse, and Rat.
Description
Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian Target of Rapamycin (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals (1). mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GbL, and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GbL, and rictor (1). GbL associates with the kinase domain of mTOR and stimulates mTOR kinase activity (2). A reduction in GbL expression has been shown to decrease in vivo phosphorylation of S6K1 (2)