Description
O-GlcNAcylation is a post-translational modification where beta-D-N-acetylglucosamine (GlcNAc) is covalently linked to cytoplasmic and nuclear proteins at serine or threonine residues (1, 2). This modification is important in many cellular processes including metabolism, cell growth and morphogenesis, apoptosis, and transcription (2, 3), and research studies have implicated this modification in cancer (1). The reversible protein modification by O-GlcNAc, which has been suggested to be a nutrient and stress sensor, is catalyzed by two highly conserved enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) (4)