The RUNX2 Antibody (S465) from MyBioSource.com is a Rabbit Polyclonal antibody to AML3, CBFA1, CCD, PEBP2aA, and RUNX2. This antibody recognizes Human antigen. The RUNX2 Antibody (S465) has been shown to work in the following applications: ELISA, Flow Cytometry, Immunohistochemistry, and Western Blot.
Description
Runx2 is a member of the RUNX family of transcription factors. It is a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. It can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in the Runx2 gene have been associated with the bone development disorder cleidocranial dysplasia (CCD)