MyBioSource.com's RAT ANTI HUMAN CD3:FITC is a Rat monoclonal antibody. The RAT ANTI HUMAN CD3:FITC Antibody was generated using CD3E, and CD3e molecule as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Flow Cytometry.
Description
Rat anti Human CD3, clone CD3-12 raised against a peptide representing an invariant cytoplasmic sequence within the CD3ε chain recognizes human CD3ε. CD3 is a multimeric protein complex composed of four distinct polypeptide chains (ε, gamma, delta, ζ) that assemble and function as three pairs of dimers (ε gamma, εdelta, ζζ). The CD3 complex serves as a T cell co-receptor that associates non-covalently with the T cell receptor (TCR) (Malissen 2008; Guy and Vignali 2009; Smith-Garvin et al. 2009). CD3 is a defining feature of cells belonging to the T cell lineage and can therefore be used as T cell marker. As Rat anti Human CD3, clone CD3-12 has been specifically raised against an epitope within the epsilon peptide chain, highly conserved among species clone CD3-12 has a very broad species crossreactivity for the CD3 marker. (Jones et al. 1993; Kothlow et al. 2005)