Hamster Anti-Mouse CD3e-LE/AF MBS673136 from MyBioSource.com

Product Specs
ItemHamster Anti-Mouse CD3e-LE/AF
CompanyMyBioSource.com
Price $265.00Supplier Page View Company Product Page
Catalog NumberMBS673136
Quantity0.5 mg
ApplicationsFlow Cytometry; Immunohistochemistry; Immunoprecipitation; Western Blot
Conjugate/TagUnconjugated
FormatLow Endotoxin, Azide - Free (LE/AF)
ReactivityMouse
TargetCD3 epsilon
IsotypeIgG kappa
Clone145-2C11
HostArmenian Hamster
Antibody TypeSecondary
ImmunogenMouse CD3 epsilon (Mr 25 kDa)
CD3 epsilon, a member of the immunoglobulin superfamily of cell surface receptors, is comprised of five invariable chains ranging in size from 16-28 kDa and is closely associated with the T cell antigen receptor (TCR). It is expressed on all T cells of all mouse strains. CD3 plays a major role in signaling during antigen recognition, leading to T-cell activation. The 145-2C11 monoclonal antibody recognizes an epitope on the 25kD epsilon chain of the CD3/TCR complex. In the presence of Fc receptor-bearing accessory cells, soluble 145-2C11 can activate primed and naïve T cell in vitro. 145-2C11 can also induce redirected lysis of specific target cells by CTL clones and it can block lysis of specific target cells by antigen-specific CTL's. Immobilized 145- 2C11 can activate both normal T lymphocytes and cloned T cell lines. Under certain conditions, T cell activation by 145-2C11 may result in apoptotic cell death. ^1-6
ClonalityMonoclonal