The ICAM1 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CD54, ICAM, ICAM-1, and ICAM1. This antibody recognizes Human, Mouse, and Rat antigen. The ICAM1 Polyclonal Antibody has been shown to work in the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus