The anti-human CD278(ICOS)-R-PE Antibody from MyBioSource.com is a Mouse Monoclonal antibody. This antibody recognizes Human antigen. The anti-human CD278(ICOS)-R-PE Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Flow Cytometry.
Description
Information: The inducible costimulator (ICOS, T cell activation molecule H4) is similar to human CD28 (24% homology), and plays an analogous role in the T cell activation process. Secondary signaling through CD28 or ICOS results in discrete cytokine secretion profiles by the activated T cells.1 Signaling by either molecule is effectively down regulated by CD152 (CTLA-4) engagement.2 Human GL50 is a member of the B7 family sharing ~20% homology with CD80 (B7-1) and CD86 (B7-2), and has been shown to be the ligand for ICOS.3 Two RNA splice variants exist for this molecule, differing only in the cytoplasmic domain. 4 Antibody ANC6C6 binds to recombinant ICOS-muIg in EIA, and to the surface of HPB-MLT cells in Flow cytometry. Additionally, it blocks binding of recombinant GL50-muIg to HPB-MLT cells