The PIAS2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PIAS2, and PIASxb. This antibody recognizes Human, Mouse, and Rat antigen. The PIAS2 Antibody has been shown to work in the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS2. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS2 binds specifically to STAT4 following IL-12 stimulation and inhibits STAT4-mediated gene activation in human T cells. PIAS2 is a potent transcriptional activator of Bcl-2, but together with Bcl-6 can suppress the expression of Bcl-2