The PDCD4 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PDCD4. This antibody recognizes Human, Mouse, and Rat antigen. The PDCD4 Polyclonal Antibody has been shown to work in the following applications: Immunohistochemistry, and Western Blot.
Description
PDCD4 (programmed cell death protein 4) was identified as a suppressor of neoplastic transformation (1). It interacts with eukaryotic initiation factors eIF4AI and eIF4AII (2). PDCD4 colocalizes with eIF4A in the cytoplasm and inhibits the activity of eIF4A as an ATP-dependent RNA helicase (2). PDCD4 inhibits cap-dependent translation (2). Upon stimulation by mitogens, PDCD4 is phosphorylated on Ser67 by S6K1 kinase and then degraded through the ubiquitin pathway leading to enhanced translation and cell growth (3)