Rat Anti-Mouse CD38-APC Antibody MBS673342 from MyBioSource.com

Product Specs
ItemRat Anti-Mouse CD38-APC Antibody
CompanyMyBioSource.com
Price $385.00Supplier Page View Company Product Page
Catalog NumberMBS673342
Quantity0.1 mg
ApplicationsFlow Cytometry, Immunohistochemistry (Frozen Sections), Immunoprecipitation
Conjugate/TagAllophycocyanin (APC)
FormatAllophycocyanin (APC) Conjugate
ReactivityMouse
TargetCD38
IsotypeIgG2a kappa
Molecular Weight34,328 Da
CloneNIMR-5
HostRat
ImmunogenCD38, Mr 42-46 kDa
Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR), and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral B-lineage cells, and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCR alpha beta ^+, CD4^-, CD8^-. Murine CD38 is also expressed by all Mac-1^+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone-marrow-derived macrophages. Monoclonal antibodies to CD38 have been shown to induce B- and T-cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis.^1-8
NCBI Full Gene NameCD38 molecule
NCBI Gene AliasesADPRC 1, ADPRC1
ClonalityMonoclonal